With the 10:30, or 45 degree, release as you hold your bowling ball your hand is turned horizontal and your thumb is pointed at 10:30 on a clock, or at a 45 degree angle. This release is the most common. It also should be used as a starting point. This release gives the bowling ball a slight inward turn toward the 7 pin for right handed bowlers or toward the 10 pin for left handed bowlers. (Note: this is also called a 45 degree axis rotation).
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